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臨床試験の結果

臨床試験は患者の皆様のご参加によってはじめて実施が可能です。その貴重なデータを公表し、今後の医療に貢献することは、試験を計画する者として重要な責務であります。患者の皆様にご参加頂いた臨床試験については、その結果を論文として公表しております。最近の臨床試験の論文は以下の通りです。詳細をお尋ねになりたい方は、直接、担当主治医にお尋ねください。

診療科 論文タイトル 掲載論文
消化器内科 Intragastric acidity during the first day following administration of low-dose proton pump inhibitors: a randomized crossover study. Clin Res Hepatol Gastroenterol.
37(3):296-301.2013 Jun.
耳鼻咽喉・頭頸部外科 Randomized double-blind study of prophylactic treatment with an antihistamine for seasonal allergic rhinitis. Int Arch Allergy Immunol.
162(1):71-8.2013 Aug.
精神神経科 Effectiveness of Information Technology Aided Relapse Prevention Programme in Schizophrenia excluding the effect of user adherence: a randomized controlled trial. Schizophr Res.
150(1):240-4.2013 Oct.
婦人科 Daily low-dose cisplatin-based concurrent chemoradiotherapy in patients with uterine cervical cancer with emphasis on elderly patients: a phase 2 trial. Int J Gynecol Cancer.
23(8):1453-8.2013 Oct.
神経内科 Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome. Neurol Neurosurg Psychiatry.
84(12):1346-8.2013 Dec.
こどものこころ診療部 Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study. Neuropsychiatr Dis Treat.
10:147-51.2014 Jan 24.
循環器内科 Efficacy and safety of low-dose clopidogrel in Japanese patients after drug-eluting stent implantation: a randomized pilot trial. Heart Vessels.
29(1):1-6.2014 Jan.
肝胆膵外科 Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T-cell differentiation in patients undergoing pancreatoduodenectomy. Surgery.
155(1):124-33.2014 Jan.
整形外科 Multicenter prospective nonrandomized controlled clinical trial to prove neurotherapeutic effects of granulocyte colony-stimulating factor for acute spinal cord injury: analyses of follow-up cases after at least 1 year. Spine (Phila Pa 1976).
1;39(3):213-9.2014 Feb.
食道・胃腸外科 Preoperative hepatic CT perfusion as an early predictor for the recurrence of esophageal squamous cell carcinoma: initial clinical results.  Oncol Rep.
31(3):1083-8.2014 Mar.
眼科 Pneumatic displacement with intravitreal bevacizumab for massive submacular hemorrhage due to polypoidal choroidal vasculopathy. Clin Ophthalmol.
3;8:485-92.2014 Mar.
精神神経科 Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study. Neuropsychiatr Dis Treat.
5;10:719-22.2014 May.
消化器内科 A phase I/II study of S-1 with sorafenib in patients with advanced hepatocellular carcinoma. Invest New Drugs
32(4):723–728.2014 Aug.
糖尿病・代謝・内分泌内科 Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with α-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on sulfonylurea alone (SUCCESS-2): a multicenter, randomized, open-label, non-inferiority trial. Diabetes Obes Metab.
16(8):761-5.2014 Aug.
消化器内科 A phase I/II trial of capecitabine combined with peginterferon α-2a in Patients with sorafenib-refractory advanced hepatocellular carcinoma. Invest New Drugs.
32(4):762–768.2014 Aug.
神経内科 Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase I/II open label clinical trial. Intern Med.
53(17):1927-31 2014 Sep 1.
婦人科 Effects of Metformin on Endmetrial Cancer Cell Growth in Vivo: A Preoperative Prospective Trial. Cancer.
120(19):2986-95.2014 Oct 1.
臨床腫瘍部 Phase II study of carboplatin, docetaxel and bevacizumab for chemotherapy-naïve patients with advanced non-squamous non-small cell lung cancer. Int J Clin Oncol. 2014 Oct 11.
消化器内科 Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers. World J Gastroenterol. 21;20(43):16318-2.2014 Nov.
皮膚科 Ultra-pure soft water improves skin barrier function in children with atopic dermatitis: a randomized, double-blind, placebo-controlled, crossover pilot study. J Dermatol Sci.
76(3):269-71.2014 Dec.
臨床試験部 Japanese POEMS syndrome with Thalidomide(J-POST) Trial: study protocol for a phase Ⅱ/Ⅲ multicentre, randomised, double-blind, placebo-controlled trial. BMJ Open.
5(1):e007330.2015 Jan 8.
血液内科 A phase 1/2 study of bosutinib in Japanese adults with Philadelphia chromosome-positive chronic myeloid leukemia. Int J Hematol.
101(2):154-64.2015 Feb.
臨床試験部 A double-blind randomized Phase II study of olanzapine 10 mg versus 5 mg for emesis induced by highly emetogenic chemotherapy. Jpn J Clin Oncol.
45(2):229-31.2015 Feb.
糖尿病・代謝・内分泌内科 Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on metformin or pioglitazone alone (Study for an Ultimate Combination Therapy to Control Diabetes with Sitagliptin-1): A multicenter, randomized, open-label, non-inferiority trial. J Diabetes Investig.
6(2):182-91.2015 Mar.
消化器内科 Sorafenib treatment in Child–Pugh A and B patients with advanced hepatocellular carcinoma: safety, efficacy and prognostic factors. Invest New Drugs
Jun 33 729-39 2015 Apr 12.
耳鼻咽喉・頭頸部外科 Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis. Int Arch Allergy Immunol.
166:177-188.2015 Apr 18.
神経内科 A single blind randomized controlled clinical trial of mexiletine in amyotrophic lateral sclerosis: Efficacy and safety of sodium channel blocker phase II trial. Amyotroph Lateral Scler Frontotemporal Degener.
16(5-6):353-8. 2015
食道・胃腸外科 Synthetic polyglycomer short-term absorbable sutures vs. polydioxanone long-term absorbable sutures for preventing incisional hernia and wound dehiscence after abdominal wall closure: a comparative randomized study of patients treated for gastric or colon cancer. Surg Today.
2015 Jul;45(7):841-5.
doi:10.1007/s00595-014-1103-1.
Epub 2015 Jan 6.
麻酔・疼痛・緩和医療科 Submental negative pressure application decreases collapsibility of the passive pharyngeal airway in nonobese women. J Appl Physiol (1985).2015 Apr 1;118(7):912-20.
doi:10.1152/japplphysiol.00158.2014.Epub 2015 Jan 22.
呼吸器内科 A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene. Springerplus.
4:358.2015 Jul 16.
臨床腫瘍部 Phase II study of carboplatin, docetaxel and bevacizumab for chemotherapy-naïve patients with advanced non-squamous non-small cell lung cancer. Int J Clin Oncol.
20(4):659-67.2015 Aug.
整形外科 Single Intradiscal Administration of the Tumor Necrosis Factor-Alpha Inhibitor, Etanercept, for Patients with Discogenic Low Back Pain. Pain Med.
2015 Aug 4.
整形外科 Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis. Yonsei Med J.
56(5):1379-83.2015 Sep;
循環器内科 Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in Japanese patients with stable coronary artery disease. Circ J.
79(11):2439-44.2015
遺伝子診療部 Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial). BMJ Open.
2015 Dec 1.
精神神経科 Milnacipran treatment and potential biomarkers in depressed patients following an initial SSRI treatment failure: a prospective, open-label, 24-week study. Neuropsychiatr Dis Treat.
11:3031-40.2015 Dec 10..
消化器内科 Liver function assessment according to the Albumin-Bilirubin (ALBI) grade in sorafenib-treated patients with advanced hepatocellular carcinoma. Invest New Drugs.
33(6):1257-62.2015 Dec.
消化器内科 Post-progression survival in patients with advanced hepatocellular carcinoma resistant to sorafenib. Invest New Drugs.
34(2):255-60 2016 Jan 14.
整形外科 Single intradiscal injection of the interleukin-6 receptor antibody tocilizumab provides short-term relief of discogenic low back pain; prospective comparative cohort study. J Orthop Sci.
21(1):2-6.2016 Jan.
精神神経科 Repetitive Transcranial Magnetic Stimulation Changes Cerebral Oxygenation on the Left Dorsolateral Prefrontal Cortex in Bulimia Nervosa: A Near-Infrared Spectroscopy Pilot Study. Eur Eat Disord Rev.
24(1):83-8.2016 Jan.
子どものこころの発達教育研究センター Effectiveness of a cognitive behavioural therapy-based anxiety prevention programme for children: a preliminary quasi-experimental study in Japan. Child Adolesc Psychiatry Ment Health.
15;10:4.2016 Feb.
呼吸器内科 An intrapleural administration of zoledronic acid for inoperable malignant mesothelioma patients: a phase I clinical study protocol. Springerplus.
27;5:195.2016 Feb.
婦人科 Phase II study of medroxyprogesterone acetate plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer†. Ann Oncol.
27(2):262-6.2016 Feb..
糖尿病・代謝・内分泌内科 Urinary podocalyxin levels were associated with urinary albumin levels among patients with diabetes. Biomarkers.
21(2):164-7.2016 Mar.
循環器内科 Protective effect of angiotensin II receptor blocker and calcium channel blocker on endothelial vasomotor function after everolimus-eluting stent implantation. J Cardiol.
67(3):236-40.2016 Mar.

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