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臨床試験は患者の皆様のご参加によってはじめて実施が可能です。その貴重なデータを公表し、今後の医療に貢献することは、試験を計画する者として重要な責務であります。患者の皆様にご参加頂いた臨床試験については、その結果を論文として公表しております。最近の臨床試験の論文は以下の通りです。詳細をお尋ねになりたい方は、直接、担当主治医にお尋ねください。

No. 論文タイトル 掲載雑誌 疾患等 リンク
(PubMed)
1 Submental negative pressure application decreases collapsibility of the passive pharyngeal airway in nonobese women. J Appl Physiol (1985).
118(7): 912-20
2015 Apr 1.
閉塞性睡眠時無呼吸症 https://www.ncbi.nlm.nih.gov/pubmed/25614595
2 Sorafenib treatment in Child–Pugh A and B patients with advanced hepatocellular carcinoma: safety, efficacy and prognostic factors. Invest New Drugs.
33(3):729-39.
2015 Apr 12.
進行肝細胞がん https://www.ncbi.nlm.nih.gov/pubmed/25861764
3 Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis. Int Arch Allergy Immunol.
166:177-188.
2015 Apr 18.
スギ花粉症 https://www.ncbi.nlm.nih.gov/pubmed/25895909
4 An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia. Clin Psychopharmacol Neurosci.
13(1):62-7.
2015 Apr 30.
統合失調症 https://www.ncbi.nlm.nih.gov/pubmed/25912539
5 A single blind randomized controlled clinical trial of mexiletine in amyotrophic lateral sclerosis: Efficacy and safety of sodium channel blocker phase II trial. Amyotroph Lateral Scler Frontotemporal Degener.
16(5-6):353-8.
Epub 2015 May 11.
筋萎縮性
側索硬化症
https://www.ncbi.nlm.nih.gov/pubmed/25960085
6 Synthetic polyglycomer short-term absorbable sutures vs. polydioxanone long-term absorbable sutures for preventing incisional hernia and wound dehiscence after abdominal wall closure: a comparative randomized study of patients treated for gastric or colon cancer. Surg Today.
45(7):841-5.
2015 Jul.
胃癌・大腸がん https://www.ncbi.nlm.nih.gov/pubmed/25556881
7 A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene. Springerplus.
4:358.
2015 Jul 16.
悪性中皮腫 https://www.ncbi.nlm.nih.gov/pubmed/26191485
8 Phase II study of carboplatin, docetaxel and bevacizumab for chemotherapy-naïve patients with advanced non-squamous non-small cell lung cancer. Int J Clin Oncol.
20(4): 659-67.
2015 Aug.
非小細胞肺がん https://www.ncbi.nlm.nih.gov/pubmed/25301566
9 Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in Japanese patients with stable coronary artery disease. Circ J.
79(11):2439-44
Epub 2015 Aug 27.
冠状動脈疾患 https://www.ncbi.nlm.nih.gov/pubmed/26310876
10 Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial). BMJ Open.
5(12):e009562.
2015 Dec 1.
重症川崎病 https://www.ncbi.nlm.nih.gov/pubmed/26628527
11 Milnacipran treatment and potential biomarkers in depressed patients following an initial SSRI treatment failure: a prospective, open-label, 24-week study. Neuropsychiatr Dis Treat.
11:3031-40.
2015 Dec 10.
うつ病 https://www.ncbi.nlm.nih.gov/pubmed/26677330
12 The Prevalence of Overall and Initial Lymph Node Metastases in Clinical T1N0 Thoracic Esophageal Cancer: From the Results of JCOG0502, a Prospective Multicenter Study. Ann Surg.
2015 Dec 17.
[Epub ahead of print]
胸部食道がん https://www.ncbi.nlm.nih.gov/pubmed/27420375
13 Repetitive Transcranial Magnetic Stimulation Changes Cerebral Oxygenation on the Left Dorsolateral Prefrontal Cortex in Bulimia Nervosa: A Near-Infrared Spectroscopy Pilot Study. Eur Eat Disord Rev.
24(1):83-8.
2016 Jan.
過食症 https://www.ncbi.nlm.nih.gov/pubmed/26481583
14 An intrapleural administration of zoledronic acid for inoperable malignant mesothelioma patients: a phase I clinical study protocol. Springerplus.
27;5:195.
2016 Feb.
悪性中皮腫 https://www.ncbi.nlm.nih.gov/pubmed/27026891
15 Phase II study of medroxyprogesterone acetate plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer. Ann Oncol.
27(2):262-6.
2016 Feb.
子宮体がん https://www.ncbi.nlm.nih.gov/pubmed/26578736
16 Protective effect of angiotensin II receptor blocker and calcium channel blocker on endothelial vasomotor function after everolimus-eluting stent implantation. J Cardiol.
67(3): 236-40.
2016 Mar.
ステント移植後患者 https://www.ncbi.nlm.nih.gov/pubmed/26194867
17 A Prospective Analysis of the Efficacy and Complications Associated With Deep Sedation With Midazolam During Fiberoptic Bronchoscopy. J Bronchology Interv Pulmonol.
23(2):106-11.
2016 Apr.
気管支鏡検査 https://www.ncbi.nlm.nih.gov/pubmed/27058712
18 A randomized controlled trial comparing water exchange and air insufflation during colonoscopy without sedation. Int J Colorectal Dis.
31(6):1217-2.
Epub 2016 Apr 8.
大腸内視鏡検査 https://www.ncbi.nlm.nih.gov/pubmed/27059039
19 Efficacy of palonosetron plus aprepitant in preventing chemoradiotherapy-induced nausea and emesis in patients receiving daily low-dose cisplatin-based concurrent chemoradiotherapy for uterine cervical cancer: a phase II study. Support Care Cancer.
Epub 2016 Jun 10.
子宮頸がん https://www.ncbi.nlm.nih.gov/pubmed/27286875
20 Immunonutrition suppresses acute inflammatory responses through modulation of resolvin E1 in patients undergoing major hepatobiliary resection. Surgery.
160(1):228-36.
2016 Jul.
肝胆道疾患(術後) https://www.ncbi.nlm.nih.gov/pubmed/26965712
21 A phase II trial evaluating the efficacy and safety of perioperative pirfenidone for prevention of acute exacerbation of idiopathic pulmonary fibrosis in lung cancer patients undergoing pulmonary resection: West Japan Oncology Group 6711 L (PEOPLE Study). Respir Res.
17(1): 90.
2016 Jul 22.
肺がん https://www.ncbi.nlm.nih.gov/pubmed/27450274
22 House dust mite sublingual tablet is effective and safe in patients with allergic rhinitis. Allergy.
2016 Jul 29.
アレルギー性鼻炎 https://www.ncbi.nlm.nih.gov/pubmed/27471838
23 A randomized, sham-controlled study of high frequency rTMS for auditory hallucination in schizophrenia. Psychiatry Res.
241:190-4.
2016 Jul 30.
統合失調症 https://www.ncbi.nlm.nih.gov/pubmed/27179693
24 Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol.
2016 Aug 3.
クロウ・フカセ症候群 https://www.ncbi.nlm.nih.gov/pubmed/27496680
25 Impact of chronic kidney disease on platelet inhibition of clopidogrel and prasugrel in Japanese patients. J Cardiol.
pii:S0914-5087(16)30171-X.
2016 Aug 23.
慢性腎疾患 https://www.ncbi.nlm.nih.gov/pubmed/27567173
26 Sublingual immunotherapy for allergic rhinitis: subjective versus objective tools to evaluate its success. Rhinology.
54(3):221-30.
2016 Sep.
アレルギー性鼻炎 https://www.ncbi.nlm.nih.gov/pubmed/27107025
27 A feasibility study of the clinical effectiveness and cost-effectiveness of individual cognitive behavioral therapy for panic disorder in a Japanese clinical setting: an uncontrolled pilot study. BMC Res Notes.
9(1):458.
2016 Oct 7.
パニック障害 https://www.ncbi.nlm.nih.gov/pubmed/27717407
28 Effect of mirtazapine versus selective serotonin reuptake inhibitors on benzodiazepine use in patients with major depressive disorder: a pragmatic, multicenter, open-label, randomized, active-controlled, 24-week trial. Ann Gen Psychiatry.
15:27.
2016 Oct 19.
大うつ性障害 https://www.ncbi.nlm.nih.gov/pubmed/27777607
29 A prospective, randomized study of inhaled prostacyclin versus nitric oxide in patients with residual pulmonary hypertension after pulmonary endarterectomy. Gen Thorac Cardiovasc Surg.
2016 Oct 25.
肺高血圧症 https://www.ncbi.nlm.nih.gov/pubmed/27783213
30 A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS). JMIR Res Protoc
5(4):e210.
2016 Nov 7.
ギランバレー症候群 https://www.ncbi.nlm.nih.gov/pubmed/27821382
31 Efficacy of intravenous nicorandil for fractional flow reserve assessment: study protocol for a crossover randomised trial. BMJ Open.
6(11):e012737.
2016 Nov 21.
安定冠動脈疾患 https://www.ncbi.nlm.nih.gov/pubmed/27872119
32 Sitagliptin but not alpha glucosidase inhibitor reduced the serum soluble CD163, a marker for activated macrophage, in individuals with type 2 diabetes mellitus. Diabetes Res Clin Pract.
126:138-143.
2017 Feb 16.
2型糖尿病 https://www.ncbi.nlm.nih.gov/pubmed/28237860
33 Pharmacokinetics of Standard- and Reduced-Dose Recombinant Human Soluble Thrombomodulin in Patients with Septic Disseminated Intravascular Coagulation during Continuous Hemodiafiltration. Front Med (Lausanne).
4:15.
2017 Feb 21.
播種性血管内凝固症候群 https://www.ncbi.nlm.nih.gov/pubmed/28271063
34 Effects of five-minute internet-based cognitive behavioral therapy and simplified emotion-focused mindfulness on depressive symptoms: a randomized controlled trial. BMC Psychiatry
17(1):85.
2017 Mar 4.
抑うつ症状 https://www.ncbi.nlm.nih.gov/pubmed/28259151
35 Efficacy and Safety of an Orally Administered. Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension. Circ J.
81(9):1360-1367.
Epub 2017 Apr 18.
高血圧症 https://www.ncbi.nlm.nih.gov/pubmed/28420826
36 Efficacy and safety of ipragliflozin and metformin for visceral fat reduction in patients with type 2 diabetes receiving treatment with dipeptidyl peptidase-4 inhibitors in Japan: a study protocol for a prospective, multicentre, blinded-endpoint phase IV randomised controlled trial (PRIME-V study). BMJ Open.
7(5):e015766.
2017 May 9.
2型糖尿病 https://www.ncbi.nlm.nih.gov/pubmed/28490565
37 Efficacy and Safety of Bococizumab (RN316/PF-04950615), a Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, in Hypercholesterolemic Japanese Subjects Receiving a Stable Dose of Atorvastatin or Treatment-Naïve‐Results From a Randomized, Placebo-Controlled, Dose-Ranging Study. Circ J.
81(10):1496-1505.
Epub 2017 May 23.
高コレステロール血症 https://www.ncbi.nlm.nih.gov/pubmed/28539539
38 Safety and Efficacy of Intra-articular Injection of Platelet-Rich Plasma in Patients With Ankle Osteoarthritis. Foot Ankle Int.
38(6):596-604.
2017 Jun.
変形性膝関節症 https://www.ncbi.nlm.nih.gov/pubmed/28399635
39 A Randomized Placebo-Controlled Trial of Prophylactic Dexamethasone for Transcatheter Arterial Chemoembolization. Hepatology.
doi:
10.1002/hep.29403.
2017 Jul 26.
肝細胞がん https://www.ncbi.nlm.nih.gov/pubmed/28746788
40 An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis. Allergol Int.
67(2):201-208.
Epub 2017 Jul 29.
アレルギー性鼻炎 https://www.ncbi.nlm.nih.gov/pubmed/28760534
41 Intravenous immunoglobulin for maintenance treatment of chronic inflammatory demyelinating polyneuropathy: a multicentre, open-label, 52-week phase III trial. J Neurol Neurosurg Psychiatry.
88(10):832-838.
2017 Aug 2.
慢性炎症性脱髄性多発神経炎 https://www.ncbi.nlm.nih.gov/pubmed/28768822
42 Feasibility of cognitive remediation therapy for adults with autism spectrum disorders: a single-group pilot study. Neuropsychiatr Dis Treat.
13:2185-2191.
2017 Aug 16.
自閉症スペクトラム障害 https://www.ncbi.nlm.nih.gov/pubmed/28860776
43 Transpancreatic precut papillotomy versus double-guidewire technique in difficult biliary cannulation: prospective randomized study. Endoscopy.
50(1):33-39.
Epub 2017 Oct 11.
カニューレ挿入後の胆管炎 https://www.ncbi.nlm.nih.gov/pubmed/29020689
44 Phase II study of neoadjuvant anthracycline combined with nanoparticle albumin-bound paclitaxel for human epidermal growth factor receptor 2-negative breast cancer. Mol Clin Oncol
7(6):1079-1082.
2017 Dec.
乳がん https://www.ncbi.nlm.nih.gov/pubmed/29285378
45 Exploratory study of imagery rescripting without focusing on early traumatic memories for major depressive disorder. Psychol Psychother.
doi:
10.1111/papt.12164..
2017 Dec 9.
大うつ性障害 https://www.ncbi.nlm.nih.gov/pubmed/29222850
46 Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA-associated vasculitis (LoVAS): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open.
7(12):e018748
2017 Dec 14.
ANCA関連血管炎 https://www.ncbi.nlm.nih.gov/pubmed/29247107
47 Randomised controlled trial on the effect of internet-delivered computerized cognitive-behavioural therapy on patients with insomnia who remain symptomatic following hypnotics: a study protocol. BMJ Open.
8(1):e018220
2018 Jan 30.
不眠症 https://www.ncbi.nlm.nih.gov/pubmed/29382675
48 Does cognitive behavioral therapy alter mental defeat and cognitive flexibility in patients with panic disorder? BMC Res Notes.
11(1):23.
2018 Jan 12.
パニック障害 https://www.ncbi.nlm.nih.gov/pubmed/29329597
49 N-3 polyunsaturated fatty acids improve lipoprotein particle size and concentration in Japanese patients with type 2 diabetes and hypertriglyceridemia: a pilot study. Lipids Health Dis.
17(1):51.
2018 Mar 15.
2型糖尿病・高トリグリセリド血症 https://www.ncbi.nlm.nih.gov/pubmed/29544483

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